The Overlooked Iceberg in Hyponatremia in an Elderly Patient: The Pituitary Gland

Hyponatremia, a prevalent electrolyte disorder in clinical practice, often poses diagnostic challenges due to its diverse etiologies. The authors present a complex case of a 91-year-old patient with persistent hyponatremia and postprandial hypoglycemia. Despite dietary adjustments, the hyponatremia remained refractory, prompting further investigation. Subsequent diagnostic imaging revealed a pituitary macroadenoma, shedding light on the underlying cause of the electrolyte imbalance. This case underscores the rarity of hyponatremia caused by hypopituitarism due to macroadenomas, highlighting the importance of recognizing this uncommon etiology.

Cite this article as: Miakhail MAA, Canpolat AG. The overlooked iceberg in hyponatremia in an elderly patient: the pituitary gland. Endocrinol Res Pract. Published online June 3, 2025. doi 10.5152/erp.2025.24590.